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HMGB1 protein is a small ubiquitous non-histone nuclear protein that acts as an architectural chromatin-binding factor involved in the maintenance of nucleosome structure and regulation of gene transcription by binding the minor groove of DNA 9,10
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Biotics Research places this compound broadly within metabolism of the central nervous system and says it supplies acetyl groups for the synthesis of acetylcholine, an important neurotransmitter
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