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The amount of LCA increases in murine portal veins after SG, vitamin D receptors are activated, and the production of gut-restricted TGR5 agonist cholic acid-7-sulfate (CA7S) is induced ( –/– mice, indicating that intestinal FXR and systemic TGR5 are critical molecular targets for RYGB microbiota transfer in protecting against adiposity and metabolic (Münzker et al., 2022)
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An important caveat applies to all of this: these mechanisms are described from preclinical models
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