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For example, MEK inhibitor AZD6244 and BAY-11-7085 inhibit NRF2, JQ-1 targets BD4, AG879 targets receptor tyrosine kinase TrkA, and all indirectly inhibit SLC7A11 expression (144)
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The streptozotocin (STZ)‐induced rodent model of T1DM exhibits increased skeletal muscle neutral lipid staining (specifically DAG), Ceramide Synthase 1 (involved in ceramide synthesis) protein content, long‐chain fatty acid‐acyl‐coenzyme A esters (precursors to DAG and ceramide), and several lipid metabolites such as octadecenoic acid, linoleic acid, arachidonic acid, docosahexaenoic acid, and palmitic acid, despite well to moderately controlled glycemia with insulin treatment (Dotzert et al., 2016
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