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Differentiation was confirmed by alizarin red staining, which detects mineralized matrix deposition, and oil red O staining, which identifies lipid vacuoles in adipocytes
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From a clinical point of view, HD is characterized by the presence of choreic movements (and, less frequently, other movement disorders, including bradykinesia, rigidity, dystonia, gait disorders, and/or tics), a wide variety of psychiatric symptoms (mainly depression or low mood and, less frequently, anxiety disorders, schizophrenic-like psychosis, emotional lability, or apathy), and progressive cognitive impairment that mainly affects executive attention function [1,2,3,4]
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