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Therefore, except for proteins, such as the transcription factor c-Jun, that display unusually high thiol redox potentials (K mix ~13) [52], the thiol–disulfide exchange reaction is not a likely mechanism for S-glutathionylation, and proteins shown to be S-glutathionylated by GSSG in vitro may not reflect what occurs in vivo

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To address this, vendors are investing in internal training programs, retraining HPC and AI engineers, and expanding partnerships with universities, although meaningful workforce expansion is expected to take 4–7 years