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Noting spontaneous decomposition of biotinyl-AMS ( 28.2 ) via cyclization to N 3 -5′-cycloadenosine ( 28.4 ) [104], they investigated the corresponding sulfamide, biotinyl-AMSN ( 28.3 ), which does not undergo this decomposition pathway and showed that it is a potent biochemical inhibitor and exhibits promising in vitro antibacterial activity against M
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