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Interestingly, GSTO1 was identified as one of the potential cellular targets of piperlongumine, an electrophilic compound exerting selective cytotoxicity against cancer cells through an oxidative cell death mechanism (Supplementary Table 25) 37
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Nagasawa (Center for Drug Design, University of Minnesota), a mentor and pioneer in the synthesis of glutathione derivatives, who sadly passed away in August 2024 during the course of this study
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