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Conversely, proinflammatory cytokines such as IL-1β, IL-6, tumor necrosis factor alpha (TNF-α), interferon gamma (INF-γ), and high mobility group box 1 protein (HMGB1) [5,21,43,66] have been observed to be downregulated along with adhesion molecules (such as vascular cell adhesion molecule 1 (VCAM-1) or intercellular adhesion molecule 1 (ICAM-1)) [21,67,68,69,70]
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