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Gastric co-administration of subthreshold dose of lectins and paraquat can induce a range of PD-like neurodegenerative processes and pathological changes, including misfolded α-synuclein in the dorsal motor nucleus and substantia nigra, a loss of dopaminergic neurons in the substantia nigra, and Parkinson-related behavioural deficits that are responsive to L-DOPA therapy 74
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the translational gaps in preclinical animal models recapitulating human-specific immunometabolic pathologies
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