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Research published through the NIH and in peer-reviewed endocrinology literature suggests that many of testosterone’s effects on body composition, bone density, insulin sensitivity, and mood are most apparent when levels are maintained in the mid-to-upper physiological range — not at the lower boundary of “acceptable.” Some research suggests that men with higher testosterone within the physiological range have better metabolic profiles, lower rates of metabolic syndrome markers, and better physical function outcomes, though individual variation is significant