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To ensure the relevance and quality of the studies included in this review, we implemented the following inclusion and exclusion criteria: Inclusion criteria: Studies published in peer-reviewed journals Articles written in English Research focused on the p53-MDM2 interaction in cancer Studies investigating natural compounds (e.g, polyphenols, terpenoids, alkaloids) with potential anticancer properties Studies providing mechanistic insights, including molecular and cellular effects of the natural compounds Both in vitro and in vivo studies