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Notably, the BBB limits the entry of neurotoxic substances from the periphery and contributes to maintenance of a stable microenvironment for optimal neuronal function to prevent critical CNS damage (Abbott et al., 2010)
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The ability of insulin to exert vasodilator action in the vascular endothelium as a result of increased nitric oxide (NO) production is an important component of the ability of this hormone to enhance glucose uptake by skeletal muscle
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