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Depicts MTHFR variant activity For example, an individual who is heterozygous at both C677T (C/T) and A1298C (A/C), known as a compound heterozygote, is expected to exhibit a 55% decrease in MTHFR enzymatic activity (‐35% activity due to the presence of one T allele at C677T and ‐20% activity due to the presence of one C allele at A1298C = ‐55%)

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Lab Tests and Professional Follow-Up Every 3 months, check: • IGF-1 and IGFBP-3 (GH bioactivity) • Fasting glucose and HbA1c (insulin sensitivity) • Thyroid panel (TSH, free T3, free T4) • Cortisol (if fatigue symptoms persist) Work with an endocrinologist to interpret labs and fine-tune your sermorelin dosage