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Blockade of BRD4–HiBiT degradation by MLN4924 and carfilzomib was not observed at higher concentrations approaching 10 µM, which we suspect is because of the transcriptional consequences of BET bromodomain inhibition, as JQ1 itself decreases BRD4–HiBiT signal at these high concentrations (Extended Data Fig
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Our findings highlight the impact of metabolic reprogramming within the niche as metastases progress and suggest clinical potential for targeting this pathway in colorectal cancer
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