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For example, the principle of using a non-uniform magnetic field to manipulate magnetic nanoparticles is based on the fact that the strength of the magnetic field gradient decreases with distance from the magnetic field source, and thus the force applied to the magnetic nanoparticles decreases with distance as well, which can affect the retention time of the nanoparticles in the blood flow and their ability to break down clots depending on the velocity of the blood flow [58]