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In general, GPX4 homeostasis is affected by both selenocysteine biosynthesis/uptake (35, 42) and GSH synthesis (43, 44),implying that GPX4 is important in regulating ferroptosis
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The Shoubridge group then concluded that the purpose of the reduced mtDNA copy number in early PGCs to ∼200 mtDNAs is to permit selection against cells with high percentages of deleterious mtDNA mutations
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